Play Alien Syndrome Online
You blast through cramped spaceship corridors as aliens swarm from every vent, scrambling for ammo while trying to rescue hostages before some nightmare boss fills the whole screen. That slow, chunky MS-DOS movement makes every close call feel desperate.

Alien Syndrome on MS-DOS is like someone took Gauntlet, dumped it into a spaceship, and cranked the alien horror up to 11. You're this lone marine—armed with way too little ammo—shooting through corridors packed with skittering, screeching creatures. At first it feels manageable, but by level three you're backpedaling like crazy, praying for a health pickup while some multi-legged horror chases you into a dead end.
The hostages are a nice touch—if you can spare the time to save them between waves. And those bosses? Pure panic fuel, filling half the screen with glowing weak points you'll miss half the time because you're too busy dodging. The DOS version's a bit slower than the arcade original, but that just means you get to savor every near-death moment. The pixel art's grimy in the best way, all flickering lights and pulsating alien eggs. Just don't expect mercy—this game plays for keeps.
Each game uses different controls, most DOS games use the keyboard arrows. Some will use the mouse , "Alt" ,"Enter" and "Space bar".

Download Alien Syndrome ROM
You can download this ROM to play Alien Syndrome offline using an MS-DOS emulator (Top Emulators).
*This ROM is provided for backup and educational purposes only.