The story is set in 1997, 10 years after its production. The plot follows Zak (full name Francis Zachary McKracken), a writer for the National Inquisitor, a tabloid newspaper (the name is a thinly veiled allusion to the National Enquirer); Annie Larris, a freelance scientist; and Melissa China and Leslie Bennett, two Yale University coed students, in their attempt to prevent the nefarious alien Caponians (who have infiltrated the phone company) from slowly reducing the intelligence of everybody on Earth using a 60 Hz "hum". The Skolarians, another ancient alien race, have left a defense mechanism hanging around to repulse the Caponians, which just needs a quick reassembly and start-up. Unfortunately, the parts are spread all over Earth and Mars.
Each game uses different controls, most DOS games use the keyboard arrows. Some will use the mouse , "Alt" ,"Enter" and "Space bar".