Play Mutant DNA Online

Mutant DNA came out in 1996 as part of the MS-DOS Classic Games collection, developed by Yeonwoo Soft. It was a time when fighting games were experimenting with new mechanics, and this one stood out for its unusual premise and surprisingly responsive controls. The game didn't try to compete with the big arcade ports; it offered something smaller, weirder, and distinctly its own.

You control a mutant fighter, selecting from a roster with varied abilities, and engage in one-on-one combat across several stages. The main objective is to defeat your opponent using a combination of basic attacks and special moves, many of which involve genetic or biological themes. Signature mechanics include a combo system that rewards timing, character-specific transformations that alter your move set, and mouse-driven inputs for certain special commands. The pacing is methodical, not overly fast, and the difficulty can spike unexpectedly against later opponents. It feels tactile and inventive, a game that makes you appreciate its oddball ideas once you get the hang of it.

Each game uses different controls, most DOS games use the keyboard arrows. Some will use the mouse , "Alt" ,"Enter" and "Space bar".