Play Chamber of the Sci-Fi Mutant Priestess Online

Chamber of the Sci-Fi Mutant Priestess is one of those weird, wonderful MS-DOS games that sticks with you. You wake up in this eerie dungeon—half sci-fi lab, half ancient temple—with no idea how you got there. The pixel art is moody as hell, all flickering lights and strange symbols on the walls, and the soundtrack? Just a low hum that makes your shoulders tense up every time you turn a corner.

At first, it feels like a straightforward dungeon crawler, but then you meet the mutants. Some look like melted robots, others like something out of a nightmare biology textbook. And the priestess? She’s this unsettling figure who keeps appearing in visions, whispering riddles that actually matter later. The puzzles are the kind where you’ll scribble notes on scrap paper, and combat’s clunky in that old-school way where positioning matters more than reflexes.

It’s janky, cryptic, and absolutely dripping with atmosphere—like if someone mashed together a 90s PC RPG with a David Lynch film. Not for everyone, but if you love games that don’t hold your hand and ooze weird charm, this one’s a trip.

Each game uses different controls, most DOS games use the keyboard arrows. Some will use the mouse , "Alt" ,"Enter" and "Space bar".