Up to three simultaneous players control the monsters George (gorilla), Lizzie (a Godzilla-like reptile), or Ralph (a giant werewolf), created from humans who were mutated by various methods. They need to destroy all buildings in a high-rise city to advance to the next city. On their way they can destroy helicopters, tanks, taxis, police cars, boats and trolleys, as well as eat people. The monsters can jump and climb buildings, and attack enemies and buildings with punches. Buildings also take damage when jumped on. The player receives damage from enemy bullets, grenades, shells, etc, or from accidental falls. Damage can be recovered by eating the right food, such as fruit, roast chicken, or soldiers. If a monster takes too much damage, it reverts back into a human and begins walking off screen. If the player continues, the human will mutate back into the monster with a full life bar. Smashing open windows generally reveals an item or person of interest, which may be either helpful or harmful. Helpful items include food or money, dangerous ones include bombs, electrical appliances and cigarettes. Some items can be both, for example a toaster is dangerous until the toast pops up, and a photographer must be eaten quickly before he dazzles the player's monster with his flash, causing it to fall. Each monster eats a "significant other" type of civilian, for instance George, who resembles King Kong, gets a large score bonus for grasping a lady in a red dress. This also causes the enemy soldiers to withdraw temporarily.
Each game uses different controls, most DOS games use the keyboard arrows. Some will use the mouse , "Alt" ,"Enter" and "Space bar".