Play Dexter's Lab - Chess Challenge (U)(Venom) Online

Game Overview

Dexter’s Lab: Chess Challenge is exactly what it sounds like—chess, but with way more test tubes and Dee Dee interrupting your strategy. The pieces look like they’ve been pulled straight from Dexter’s lab (robots, beakers, the works), and the animations have that same chaotic energy as the cartoon. Even the AI opponents feel like characters—Dee Dee’s moves are somehow both terrible and brilliant, just like in the show.

It’s still chess at its core, but with enough personality to make it feel fresh. The puzzles are a nice touch if you want a break from standard matches, though good luck focusing when Dexter’s smug little face pops up every time you take too long. If you grew up watching the show, this is a weirdly perfect nostalgia trip. Just don’t expect a deep chess sim—it’s more about the vibe than grandmaster-level play.

Also, yes, Dee Dee will absolutely wreck you if you underestimate her.